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Thursday, August 04, 2005

Synthesis of Phosphate Monoesters

The following paper presents an efficient and environmentally friendly method for producing phosphate monoesters, in which the only byproduct is water, as opposed to a different reaction, which also gives off pyridine hydrochloride as a byproduct.
The paper describes that it was experimentally determined that the best solvent, tertiary amine, and catalyst (or nucleophilic base) for the reaction are DMF-nitroethane, tributylamine, and N-butylimidazole, respectively, each giving the highest yield. This is a summary of the main reaction discussed in the paper.
* The article states that water was constantly removed by azeotropic reflux, so that the reverse reaction was prevented.

Article Link

I have also included an interesting extensive study on phosphate monoesters.


  • It is a good example but fix:
    1) your citations are incomplete in CiteULike
    2) butyl misspelled in a few places
    3) the reaction you drew is reversible - what prevents the water from reacting with the phosphate ester?

    By Blogger Jean-Claude Bradley, at 9:08 PM  

  • Full marks. Fix the spelling of azeotropic in your text.

    By Blogger Jean-Claude Bradley, at 7:27 AM  

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