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Friday, July 22, 2005

Synthesis of Lupinine Esters from Betulonic Acid Chloride




The reaction shown above outlines the synthesis of the lupinine ester. These esters have been studied for their biological properties. Found mainly in plants there is heavy research being done on them for their antiviral, antitumor and hepatoprotective activity. In some cases lupinine esters can exhibit local anesthetic properties.

The reaction shows how you would synthesize a lupinine ester from betulonic acid chloride with lupinine. Side conditions for this reaction include the presence of triethylamine and must be performed in dry CCl4.

CiteULike Reference

1 Comments:

  • 8/10. Great example of ester formation. But how does C=O get to C=X and there are no reagents on the arrow? It happened because you copied the pics directly from the article, where they were used in a different context. Yes, it is a pain to redraw the molecules in ChemSketch but you'll thank me later.

    By Blogger Jean-Claude Bradley, at 6:38 AM  

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