Organic Chemistry II Subscribe with Bloglines class wiki class vodcast

Thursday, July 07, 2005

Lindlar's Catalyst


The above is one of the final reactions in the synthesis of an enantiospecifically labeled fatty acid. It involves a reduction with Lindlar's Catalyst in the presence of deuterium, an isotope of hydrogen. Lindlar's Catalyst (powdered barium sulfate coated with Pd, poisoned with quinoline) converts an alkyne to a cis-alkene, as seen in the reaction above. The article I looked at focused on pheromone biosynthesis in S. isatideus and the role stereochemistry played. Article Link.

10 Comments:

  • sorry, i have to change the size of the picture. when i minimized it in paint the clarity also went..

    By Blogger shailja, at 12:38 PM  

  • 1) Yes you need to correct the picture width a bit
    2) Lindlar's catalyst is a good example just do that single step ( from alkyne to alkene), not multiple steps
    3) this reduction is not done with any atom A but a very specific one in the paper

    By Blogger Jean-Claude Bradley, at 1:41 PM  

  • 4) the citation info is incomplete in citeulike

    By Blogger Jean-Claude Bradley, at 1:46 PM  

  • correct the spelling of quinoline and article and you are done
    Full Marks

    By Blogger Jean-Claude Bradley, at 3:49 PM  

  • lindlars catalyst is Pd on Calcium Carbonate, Pd on Barium Sulfate is the Rosenmundts Catalyst.

    By Anonymous Anonymous, at 9:39 AM  

  • Are there any problems with the semi-hydrogenation of alkynes using linlar catalyst and quinoline... my experimental went wrong and cant find anywhere why it would have done

    By Anonymous Anonymous, at 5:02 AM  

  • I have not used Lindlar's catalyst in the lab - I would suggest try to email the orglist:
    http://www.orglist.net

    By Blogger Jean-Claude Bradley, at 5:24 AM  

  • hi shailja i m agree with u and disagree with this anonymous who have written that lindar catalyst is Pd-CaCO3.actually it is both Pd with CaCO3 and Pd with BaSO4.......DEPENDING ON THE CONDITIONS WITH WITH IT IS GIVING MOST OPTIMISED CHEMICAL REACTION............

    By Blogger raj, at 3:21 PM  

  • u r rt raj.... actually Pd/BaSO4 can also be used for ROSENMUND'S reaction... i.e synthesys of aldehydes from their acid chlorides(exept formaldehyde as formylchloride is unstable at room temparature).

    By Blogger madhuri, at 12:18 PM  

  • for raj...
    we atleast....
    I does not concern with this that what is lindlar's catalyst...i only concern that in may paper which one of the below formula of this catalyst is correct??
    pd+CACO3
    OR
    pd+BaSO4???

    By Anonymous Aisha, at 5:40 AM  

Post a Comment

<< Home