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Friday, July 08, 2005

The dioxygenase-catalysed formation of vicinal cis-diols
























This is an example of the reaction of an epoxide ring reacting with water and and enzyme (epoxide hydrolase) to create a vicinal diol. The paper displays experiments with several different compounds and the role of mono- and di-oxygenase enzymes in arene
metabolism. The paper also displays a variety of intermediary or alternative pathways the the substrates can take to generate different, but useful products. The primary focus is on the impressive ability of bacterial oxygenases to catalyse the cisdihydroxylation
of a diverse range of arenes and alkenes to yield a single enantiomer.

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1 Comments:

  • 5/10 marks
    1) The reaction you drew is wrong. You do not create C=C double bonds.
    2) The article you listed in CiteULike does not have the reaction you drew. You should have put the first article in CiteULike and have just one reference.
    3) The size of your atoms is borderline -see how clearly the molecules show up in some of the other student posts.

    By Blogger Jean-Claude Bradley, at 7:26 AM  

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