Catalytic hydrogenation of an ether to an alcohol
This is one of the synthesis steps to produce tolterodine tartrate. The focus of the study was to find a cost-effective and impurity-free process to produce tolterodine tartrate. This compound is a muscle relaxant used to treat bladder disorders. Although ethers are inert to most reagents, a benzyl ether, like the one above, can be hydrogenated under mild conditions (H2/Raney/Ni/MeOH/25-30 C) to an alcohol. The phenyl group stays and the methylbenzene group leaves. Article link.