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Thursday, July 21, 2005

Catalytic Hydrogenation of an Acid




















This reaction is an example of the catalytic hydrogenation of an acid in an ionic liquid similar to the reagents sodium metal/liquid ammonia discussed in lecture. This particular reaction has sorbic acid and hydrogen gas reacting with a ruthenium catalyst and a biphasic 1-butyl-3-methyl imidazolium hexafluorophosphate (bmimPF6)/methyl tert-butyl ether (MTBE) system to create cis-hex-3-enoic acid. The above reaction occurs with ~85% selectivity. The author of this paper was examining enantioselective hydrogenation in ionic liquids because this mechanism could provide a means for facile recycling of metal complexes of expensive chiral ligands. The author also studies some hydrogenation reactions that lead to the precursor of the antiinflammatory drug ibuprofen, the active ingredient in Advil.

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3 Comments:

  • 1) Your CiteULike link does not work-see other student posts to see how to do it
    2) define all abbreviations
    3) there are no alcohols in your structures

    By Blogger Jean-Claude Bradley, at 8:25 AM  

  • 1) Full citation info still missing in CiteULike.
    2) It is difficult to tell that there are double bonds in the structures

    By Blogger Jean-Claude Bradley, at 2:31 PM  

  • Full Marks. I can see your double bonds now.

    By Blogger Jean-Claude Bradley, at 6:56 AM  

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